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When given with other diureticsamiloride may cause a loss of too much body waterdehydrationand salt/mineralsTell your doctor right away if you have any of these unlikely but serious symptoms of dehydration or mineral lossvery dry mouthextreme thirstmuscle crampsweaknessfast heartbeatsevere dizzinessconfusionfaintingseizures.

Antikaliuretic therapy should be instituted only with caution in severely ill patients in whom respiratory or metabolic acidosis may occursuch as patients with cardiopulmonary disease or poorly controlled diabetesIf MIDAMORamilorideis given to these patientsfrequent monitoring of acid-base balance is necessaryShifts in acid-base balance alter the ratio of extracellular/intracellular potassiumand the development of acidosis may be associated with rapid increases in serum potassium levels.

HOW TO USETake this medication by mouth with foodusually once daily or as directed by your doctor.If you take this drug too close to bedtimeyou may need to wake up to urinateThereforeit is best to take this medication at least 4 hours before your bedtimeIf you have any questions about how and when to take this medicationask your doctor or pharmacist.The dosage is based on your medical condition and response to treatment.Use this medication regularly in order to get the most benefit from itTo help you remembertake it at the same time each dayIt is important to continue taking this medication even if you feel wellMost people with high blood pressure do not feel sick.Tell your doctor if your condition does not improve or if it worsenssuch as your blood pressure readings remain high or increase

WARNINGThis medication can cause high potassium levelshyperkalemiaThis effect is more likely to occur in older adults and in patients with kidney diseasediabetesor a serious illnessPotassium levels must be closely monitored on a regular basis while taking this medicationIf not treatedvery high potassium levels can sometimes be fatalTell your doctor immediately if you develop any symptoms of high potassium levelsincluding muscle weaknessslow/irregular heartbeatnumb/tingling skin.

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