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ALTITUDEAliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpointswas a study designed to test the benefit of adding aliskiren to a standard therapy of an ACE inhibitor or an angiotensin II receptor blocker in patients with type 2 diabetes mellitus and chronic kidney diseasecardiovascular diseaseor bothThe study was terminated early because of an increased risk of adverse outcomesCardiovascular death and stroke were both numerically more frequent in the aliskiren group than in the placebo group and adverse events and serious adverse events of interesthyperkalaemiahypotension and renal dysfunctionwere more frequently reported in the aliskiren group than in the placebo group.

The recommended starting dose in adult patients with hypertension taking diuretics is 5 mg once per day.

ONTARGET was a study conducted in patients with a history of cardiovascular or cerebrovascular diseaseor type 2 diabetes mellitus accompanied by evidence of end-organ damageVA NEPHRON-D was a study in patients with type 2 diabetes mellitus and diabetic nephropathy.

A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.

Treatment of renal disease in hypertensive patients with Type 2 diabetes mellitus and incipient nephropathysee section 5.1

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