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Antitumor responses for patients with disease resistant to both paclitaxel and an anthracycline are shown in Table 19.

XELODA in combination with docetaxel resulted in statistically significant improvement in time to disease progressionoverall survival and objective response rate compared to monotherapy with docetaxel as shown in Table 17Figure 4and Figure 5.

Figure 2 Kaplan-Meier Estimates of Overall SurvivalAll Randomized Population)

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patients and patients caregivers should be informed of the expected adverse effects of xeloda, particularly nausea, vomiting, diarrhea, and hand-and-foot syndrome, and should be made aware that patient-specific dose adaptations during therapy are expected and necessary see dosage and administration 2.

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