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I had been on premarin for 5 years without progesterone and had started to spot.

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If pregnancy occurs during medication with Premarin treatment should be withdrawn immediatelyThe results of most epidemiological studies to date relevant to inadvertent foetal exposure to estrogens indicate no teratogenic or foetotoxic effects.

If you are nearsighted or wear contact lensesyou may develop vision problems or trouble wearing your contact lensesContact your eye doctor if these problems occur.

Other binding proteins may be elevated in serumi.ecorticoid binding globulinCBGsex-hormone-binding globulinSHBGleading to increased circulating corticosteroids and sex steroidsrespectivelyFree or biologically active hormone concentrations are unchangedOther plasma proteins may be increasedangiotensinogen/renin substratealpha-I-antitrypsinceruloplasmin

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An increased risk of stroke and DVT has been reported with estrogen-alone therapyAn increased risk of PEDVTstroke and MI has been reported with estrogen plus progestin therapyShould any of these occur or be suspectedestrogen with or without progestin therapy should be discontinued immediatelyRisk factors for arterial vascular diseasefor examplehypertensiondiabetes mellitustobacco usehypercholesterolemiaand obesityand/or venous thromboembolismVTEfor examplepersonal history or family history of VTEobesityand systemic lupus erythematosusshould be managed appropriately.

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you and your healthcare provider should talk regularly for example, every 3 to 6 months about the dose you are taking and whether you still need treatment with premarin.

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