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The observed trough concentrations described above pertain to oral administration of Prograf onlywhile monitoring Prograf concentrations in patients receiving Prograf injection as a continuous IV infusion may have some utilitythe observed concentrations will not represent comparable exposures to those estimated by the trough concentrations observed in patients on oral therapy.

ISMP Canada has informed Health Canada about the Canadian report received and the information highlighted in this articleAstellas Pharma Canada Incthe manufacturer of both Prograf and Advagrafis also aware of these issues and is supportive of ISMP Canada sharing this informationAstellas Pharma Canada Inc is working to implement various measures to reduce the potential for mix-ups between Prograf and Advagraf.

Prograf is indicated for the prophylaxis of organ rejection in patients receiving allogeneic kidneytransplantsIt is recommended that Prograf be used concomitantly with azathioprine or mycophenolate mofetilMMFand adrenal corticosteroidssee Clinical StudiesTherapeutic drug monitoring is recommended for all patients receiving Prografsee DOSAGE AND ADMINISTRATION

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although there is no clinical experience with advagraf in lung-, pancreas- or intestine-transplanted patients, prograf has been used in lung-transplanted patients at an initial oral dose of 0.

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