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Hydrochlorothiazide should not be used for gestational edemagestational hypertension or preeclampsia due to the risk of decreased plasma volume and placental hypoperfusionwithout a beneficial effect on the course of the disease.

When amiloride hydrochloride is administered concomitantly with an angiotensin-converting enzyme inhibitorangiotensin II receptor antagonisttrilostaneciclosporin or tacrolimusthe risk of hyperkalaemia may be increasedThereforeif concomitant use of these agents is indicated because of demonstrated hypokalaemiathey should be used with caution and with frequent monitoring of serum potassium.

Capoten TabletsConsumer Medicines Information leaflets of prescription and over-the-counter medicines.

Hepatic diseaseThiazides should be used with caution in patients with impaired hepatic function or progressive liver diseasesee 4.3Contraindicationssince minor alterations of fluid and electrolyte balance may precipitate hepatic coma.

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