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A 2011 review found insufficient evidence to determine the effect of naltrexone take by mouth in opioid dependence.

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REVIA has not been shown to provide any therapeutic benefit except as part of an appropriate plan of management for the addictions.

Alcohol-and opioid-dependent patientsincluding those taking REVIAshould be monitored for the development of depression or suicidal thinkingFamilies and caregivers of patients being treated with REVIA should be alerted to the need to monitor patients for the emergence of symptoms of depression or suicidalityand to report such symptoms to the patient’s healthcare provider.

Irrespective of the drug chosen to reverse REVIA blockadethe patient should be monitored closely by appropriately trained personnel in a setting equipped and staffed for cardiopulmonary resuscitation.

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if it s taken at a treatment center, naltrexone can be administered once a day, once every other day, once every third day, or once every day.

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