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After taking this medicine for long periods of timesuch as a year or moresome people suddenly lose the ability to moveThis loss of movement may last from a few minutes to several hoursThe person is then able to move as beforeThis condition may unexpectedly occur again and againThis problem is called theon-offeffectYour doctor may prescribe you a stronger dose of SINEMET or may ask you to take it more frequentlyYour doctor may need to prescribe you a different medicine.

Blood in the urine difficult or painful urination changes in mood such as depression forgetfulness signs of anaemiasuch as tirednessbeing short of breathand looking pale signs of frequent or worrying infections such as feversevere chillssore throat or mouth ulcers bruising or bleeding more easily than normalnose bleeds fainting skin rashitchiness pinkishitchy swellings on the skinalso called hives or nettle rash numbness or tingling in the hands or feet signs of melanomasuch as new skin spots or changes to the sizeshapecolour or edges of an existing skin spotfreckle or mole.

Abnormal uncontrolled movements including muscle twitching or spasmswhich may or may not resemble your Parkinson’s symptoms dizzinesslight-headedness when standing quickly feeling sicknauseavomitingloss of appetite discolouration of urinesweat and/or saliva dream abnormalities sleepiness or sudden onset of sleep slow movements twitching or spasm of the eyelids hair loss diarrhoea.

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking SINEMET.

If you are diabeticcheck with your doctor or pharmacist before using urine sugar tests.

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there is no specific dosing recommendation based upon clinical pharmacology data as sinemet is titrated as tolerated for clinical effect.

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